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{"slip": { "id": 66, "advice": "Take time once in a while to look up at the stars for at least 5 minutes, in order to comprehend your cosmic significance."}}
{"slip": { "id": 116, "advice": "One of the top five regrets people have is that they didn't stay in contact with friends."}}
{"type":"standard","title":"Ralaniten acetate","displaytitle":"Ralaniten acetate","namespace":{"id":0,"text":""},"wikibase_item":"Q25091555","titles":{"canonical":"Ralaniten_acetate","normalized":"Ralaniten acetate","display":"Ralaniten acetate"},"pageid":49581858,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/cd/Ralaniten_acetate.svg/330px-Ralaniten_acetate.svg.png","width":320,"height":111},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/cd/Ralaniten_acetate.svg/2225px-Ralaniten_acetate.svg.png","width":2225,"height":775},"lang":"en","dir":"ltr","revision":"1170387040","tid":"65c7c2fe-3ad8-11ee-81a7-1412c891917a","timestamp":"2023-08-14T19:25:59Z","description":"Chemical compound","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Ralaniten_acetate","revisions":"https://en.wikipedia.org/wiki/Ralaniten_acetate?action=history","edit":"https://en.wikipedia.org/wiki/Ralaniten_acetate?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Ralaniten_acetate"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Ralaniten_acetate","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Ralaniten_acetate","edit":"https://en.m.wikipedia.org/wiki/Ralaniten_acetate?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Ralaniten_acetate"}},"extract":"Ralaniten acetate is a first-in-class antiandrogen that targets the N-terminal domain (NTD) of the androgen receptor (AR) developed by ESSA Pharmaceuticals and was under investigation for the treatment of prostate cancer. This mechanism of action is believed to allow the drug to block signaling from the AR and its splice variants. EPI-506 is a derivative of bisphenol A and a prodrug of ralaniten (EPI-002), one of the four stereoisomers of EPI-001, and was developed as a successor of EPI-001. The drug reached phase I/II prior to the discontinuation of its development. It showed signs of efficacy in the form of prostatic specific antigen (PSA) decreases (4–29%) predominantly at higher doses (≥1,280 mg) in some patients but also caused side effects and was discontinued by its developer in favor of next-generation AR NTD inhibitors with improved potency and tolerability.","extract_html":"
Ralaniten acetate is a first-in-class antiandrogen that targets the N-terminal domain (NTD) of the androgen receptor (AR) developed by ESSA Pharmaceuticals and was under investigation for the treatment of prostate cancer. This mechanism of action is believed to allow the drug to block signaling from the AR and its splice variants. EPI-506 is a derivative of bisphenol A and a prodrug of ralaniten (EPI-002), one of the four stereoisomers of EPI-001, and was developed as a successor of EPI-001. The drug reached phase I/II prior to the discontinuation of its development. It showed signs of efficacy in the form of prostatic specific antigen (PSA) decreases (4–29%) predominantly at higher doses (≥1,280 mg) in some patients but also caused side effects and was discontinued by its developer in favor of next-generation AR NTD inhibitors with improved potency and tolerability.
"}{"fact":"In 1987 cats overtook dogs as the number one pet in America.","length":60}
{"type":"standard","title":"Bud Collyer","displaytitle":"Bud Collyer","namespace":{"id":0,"text":""},"wikibase_item":"Q2927489","titles":{"canonical":"Bud_Collyer","normalized":"Bud Collyer","display":"Bud Collyer"},"pageid":643418,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/3/3b/Bud_Collyer_1962.JPG/330px-Bud_Collyer_1962.JPG","width":320,"height":422},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/3/3b/Bud_Collyer_1962.JPG","width":563,"height":742},"lang":"en","dir":"ltr","revision":"1288634194","tid":"57ea3dcc-286d-11f0-b291-98056027c33c","timestamp":"2025-05-03T22:24:14Z","description":"American actor (1908–1969)","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Bud_Collyer","revisions":"https://en.wikipedia.org/wiki/Bud_Collyer?action=history","edit":"https://en.wikipedia.org/wiki/Bud_Collyer?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Bud_Collyer"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Bud_Collyer","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Bud_Collyer","edit":"https://en.m.wikipedia.org/wiki/Bud_Collyer?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Bud_Collyer"}},"extract":"Bud Collyer was an American radio actor and announcer and game show host who became one of the nation's first major television game show stars. He is best remembered for his work as the first host of the TV game shows Beat the Clock and To Tell the Truth, but he was also famous in the roles of Clark Kent / Superman on radio and in animated cartoons, initially in theatrical short subjects and later on television.","extract_html":"
Bud Collyer was an American radio actor and announcer and game show host who became one of the nation's first major television game show stars. He is best remembered for his work as the first host of the TV game shows Beat the Clock and To Tell the Truth, but he was also famous in the roles of Clark Kent / Superman on radio and in animated cartoons, initially in theatrical short subjects and later on television.
"}